Diabetic Woman No Longer Needs Insulin After Single Dose of Experimental Stem Cells
Diabetic Woman No Longer Needs Insulin After Single Dose of Experimental Stem Cells A Canadian woman with type 1 diabetes spent nearly a decade dependent on her glucose monitor and insulin shots — but after a single dose of manufactured stem cells implanted into her liver, she’s now free. In an interview with CTV, 36-year-old Amanda Smith […]
My eye was saved by a placenta after acid attack
My eye was saved by a placenta after acid attack A donated placenta has been used to help save a man’s eye after an acid attack. Acid was squirted into Paul Laskey’s face causing severe chemical burns to his eye, “melting” both the inner and outer layers of his cornea. He had two emergency corneal […]
World-first stem-cell treatment restores vision in people
World-first stem-cell treatment restores vision in people Three people with severely impaired vision who received stem-cell transplants have experienced substantial improvements in their sight that have persisted for more than a year. A fourth person with severely impaired vision also experienced gains in their sight, but they did not last. The four are the first […]
FDA Approves First Mesenchymal Stromal Cell Therapy to Treat Steroid-refractory Acute Graft-versus-host Disease
FDA Approves First Mesenchymal Stromal Cell Therapy to Treat Steroid-refractory Acute Graft-versus-host Disease Today, the U.S. Food and Drug Administration approved Ryoncil (remestemcel-L-rknd), an allogeneic (donor) bone marrow-derived mesenchymal stromal cell (MSC) therapy indicated for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD) in pediatric patients 2 months of age and older. Ryoncil is the […]
Exosomal miR-133b-3p modulates TGF-β1/Treg immunomodulation to ameliorate osteoporosis
Exosomal miR-133b-3p modulates TGF-β1/Treg immunomodulation to ameliorate osteoporosis Abstract Purpose Osteoporosis (OP) is influenced by dysregulated miRNAs, particularly during osteoblast differentiation. The precise mechanisms are still under debate. This study aimed to explore the impact of bone marrow mesenchymal stem cells (BMSCs)-derived exosomal miR-133b-3p on the TGF-β1/Treg-mediated immune pathway, offering insights into OP’s pathogenesis and […]
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages Abstract Background Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study, we investigated the mechanism by which human umbilical […]
Stem cell therapy found to boost fertility in women with ovarian failure
Stem cell therapy found to boost fertility in women with ovarian failure Stem cell treatment may be effective for fertility restoration in women with ovarian failure, according to a recent study published in Aging (Aging-US).1 This method was associated with a 70% oocyte activation rate and spontaneous pregnancy in 7% of participants. Additionally, 14% achieved pregnancy […]
Paralysed man stands again after receiving ‘reprogrammed’ stem cells
Paralysed man stands again after receiving ‘reprogrammed’ stem cells A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal-cord injury. The Japanese man was one of four individuals in a first-of-its-kind trial that used reprogrammed stem cells to treat people who are paralysed.
Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway
Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway Abstract Background Exosomes isolated from human umbilical cord mesenchymal stem cells (hUCMSCs) have demonstrated the capacity to alleviate dihydrotestosterone (DHT)-induced disruptions in the hair follicle growth cycle. However, the precise role and underlying mechanisms by which hUCMSC-derived […]
Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes
Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes Abstract Background Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) have gained significant attention for their potential in cellular regeneration and functional rehabilitation. Nevertheless, the rapid expansion of research in this field makes it challenging for emerging trends and strategic priorities, potentially impeding […]