China’s NMPA Approves Country’s First MSC-Based Cell Therapy, Ruibosheng
On January 2, 2025, China’s National Medical Products Administration (NMPA) granted conditional approval to Platinum Life Excellence Biotech Co. Ltd.’s amimestrocel injection (hUC-MSC PLEB-001), marking a significant milestone in the country’s medical and biotechnological advancements. The product is being marketing under the brand name Ruibosheng. This approval designates it as China’s first human umbilical cord-derived […]
Injection of human umbilical cord mesenchymal stem cells exosomes for the treatment of knee osteoarthritis: from preclinical to clinical research
Abstract Background Background: Exosomes (Exos) derived from mesenchymal stem cells (MSCs) share similar biological functions with MSCs but are more stable under various pathophysiological conditions, with a lower risk of immune rejection. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are a promising source of MSC-derived exosomes (MSC-Exos), particularly for the treatment of osteoarthritis (OA), a […]
Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair
Abstract Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond. Exosomes, small extracellular vesicles secreted by various stem cells, have emerged as potent mediators of […]
Heart defects affect 40,000 US babies every year — but cutting edge AI and stem cell tech will save lives and even cure them in the womb
By Jeanette Settembre and Megan Palin Published Nov. 8, 2024, 6:00 a.m. ET 10 Comments Katie Blue-Pugh was just a few hours old when her lips turned blue and panic suddenly set in for her parents and staff in a California maternity ward. Later that day, doctors discovered she had a major heart defect, born […]
JPM25: Bayer moves allogeneic cell therapy into phase 3 Parkinson’s trial
Bayer’s BlueRock Therapeutics is launching a phase 3 trial for Parkinson’s disease, with an expected enrollment of 102 patients. (iStock / Getty Images Plus) Bayer’s Parkinson’s disease cell therapy is moving into late-stage testing, with the upcoming trial set to be the first registrational phase 3 study for an investigational allogeneic cell therapy in the […]
Australia Allows Umbilical Cord Blood Therapy for Cerebral Palsy
June 2025 Zara was the first child in Australia to receive cord blood therapy for cerebral palsy outside of a clinical trial. In April 2025, Zara received an infusion of her own umbilical cord blood under the supervision of Dr. Michael Fahey, pediatric neurologist at Monash Children’s Hospital. The regulatory pathway that made Zara’s treatment […]
Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration
Abstract Despite significant strides in medical treatments and surgical procedures for cardiovascular diseases, these conditions continue to be a major global health concern. The persistent need for innovative therapeutic approaches to mend damaged heart tissue highlights the complexity and urgency of this medical challenge. In recent years, stem cells have emerged as a promising tool […]
Recent clinical trials with stem cells to slow or reverse normal aging processes
Abstract Aging is associated with a decline in the regenerative potential of stem cells. In recent years, several clinical trials have been launched in order to evaluate the efficacy of mesenchymal stem cell interventions to slow or reverse normal aging processes (aging conditions). Information concerning those clinical trials was extracted from national and international databases […]
Future Perspectives: Implementation of Artificial Intelligence in Umbilical Cord Biobanking
Introduction The incorporation and implementation of Artificial Intelligence (AI) into Umbilical cord biobanking is still at its developing stage, but there is a great potential that artificial intelligence will be progressively incorporated and implemented into the various aspects of umbilical cord blood biobanking. This article elaborates extensively on the various aspects of the Umbilical Cord […]
New study shows stem cell therapy ‘jump-start’ brain repair after stroke
by Gladstone Institutes Editors’ notes A team of scientists—including Agnieszka Ciesielska (left), Barbara Klein (center), and Jeanne Paz (right)—showed that modified stem cells can improve brain activity, even when administered more than a month after a stroke. Credit: Michael Short/Gladstone Institutes Every 40 seconds, someone in the United States has a stroke. For survivors of […]
