Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseases
Abstract Mesenchymal stem/stromal cells (MSCs) and their exosomes (MSC-Exos) have great potential for tissue repair and regenerative medicine, which can improve the symptoms and prognosis of aging-related diseases and potentially slow the aging process through multiple pathways. This comprehensive review summarizes the characterization of MSCs and MSC-Exos from various tissue sources and their applications in […]
Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth
y genes involved in the key pathways of Ξ²-catenin, WNT, BMP2 and BMP4 promotes the proliferation of hair follicle stem cells Control hair loss Zhou et al. (2018), Zhang et al. (2022) Fat mesenchymal stem cell exosomes Inhibit the over-expression of MMP-1, MMP-2, MMP-3 and MMP-9 induced by UV irradiation, and enhance the expression of […]
Stem cell exosomes may be hypoxic pulmonary hypertension therapy
Researchers use lab-grown cells, rats to better understand disease mechanisms Margarida Maia, PhD avatar by Margarida Maia, PhD | July 28, 2025 A dropper is seen poised above one petri dish while an aerial view shows cells in another petri dish. Share on Facebook Share on Twitter Share on Reddit Share via Email Exosomes β […]
Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging
Highlights β’ The hallmarks of aging are diverse and the features interact with each other rather than being independent of each other. This article wants to use hallmarks of aging as an entry point to explore whether improving the relevant indicators can delay aging. β’ Mesenchymal stem cells have strong tissue regeneration and repair ability, […]
Clinical applications of stem cell-derived exosomes
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared to stem cells, stem cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic potential and ethical […]
Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis
Ferroptosis, a regulated type of cell death directed by iron-dependent lipid peroxidation, is associated with a variety of pathological diseases. Recent findings have highlighted the therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in modulating ferroptosis. These nano-sized extracellular vesicles carry bioactive substances, including proteins, lipids, and microRNAs, which regulate vital pathways related to ferroptosis, […]
