Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages Abstract Background Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study, we investigated the mechanism by which human umbilical […]
Stem cell therapy found to boost fertility in women with ovarian failure
Stem cell therapy found to boost fertility in women with ovarian failure Stem cell treatment may be effective for fertility restoration in women with ovarian failure, according to a recent study published in Aging (Aging-US).1 This method was associated with a 70% oocyte activation rate and spontaneous pregnancy in 7% of participants. Additionally, 14% achieved pregnancy […]
Paralysed man stands again after receiving ‘reprogrammed’ stem cells
Paralysed man stands again after receiving ‘reprogrammed’ stem cells A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal-cord injury. The Japanese man was one of four individuals in a first-of-its-kind trial that used reprogrammed stem cells to treat people who are paralysed.
Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway
Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway Abstract Background Exosomes isolated from human umbilical cord mesenchymal stem cells (hUCMSCs) have demonstrated the capacity to alleviate dihydrotestosterone (DHT)-induced disruptions in the hair follicle growth cycle. However, the precise role and underlying mechanisms by which hUCMSC-derived […]
Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes
Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes Abstract Background Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) have gained significant attention for their potential in cellular regeneration and functional rehabilitation. Nevertheless, the rapid expansion of research in this field makes it challenging for emerging trends and strategic priorities, potentially impeding […]
FDA Approves First-Ever Cell Therapy Treatment for Rare Progressive Eye Disease
FDA Approves First-Ever Cell Therapy Treatment for Rare Progressive Eye Disease The FDA has approved the first – and only – treatment, a cell therapy, for macular telangiectasia type 2 (MacTel), a rare neurodegenerative disease that causes irreversible vision loss. The treatment, Encelto (revakinagene taroretcel-lwey), is an encapsulated cell therapy, developed by Neurotech Pharmaceuticals, that […]