‘My eye was saved by a placenta after acid attack’
Sharon Barbour Health correspondent, BBC North East and Cumbria BBC Paul Laskey is smiling. He is in a short sleeved top and sitting on his sofa at home. The white of his repaired eye is still quite red. BBC Paul Laskey’s eye has been saved with the help of a donated placenta A donated placenta […]
World-first stem-cell treatment restores vision in people
The treatment, given to four people with damaged corneas, seems safe but needs to be tested in larger trials. By Smriti Mallapaty Twitter Facebook Email Close up view of a human eye during a slit lamp eye examination. The transparent cornea is the outermost layer of the eye. Credit: Patrick Landmann/SPL Three people with severely […]
FDA Approves First Mesenchymal Stromal Cell Therapy to Treat Steroid-refractory Acute Graft-versus-host Disease
For Immediate Release: December 18, 2024 Today, the U.S. Food and Drug Administration approved Ryoncil (remestemcel-L-rknd), an allogeneic (donor) bone marrow-derived mesenchymal stromal cell (MSC) therapy indicated for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD) in pediatric patients 2 months of age and older. Ryoncil is the first FDA-approved MSC therapy. It contains MSCs, […]
Exosomal miR-133b-3p modulates TGF-β1/Treg immunomodulation to ameliorate osteoporosis
Abstract Purpose Osteoporosis (OP) is influenced by dysregulated miRNAs, particularly during osteoblast differentiation. The precise mechanisms are still under debate. This study aimed to explore the impact of bone marrow mesenchymal stem cells (BMSCs)-derived exosomal miR-133b-3p on the TGF-β1/Treg-mediated immune pathway, offering insights into OP’s pathogenesis and potential therapeutic targets. Materials and methods Bioinformatics analysis […]
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages
Abstract Background Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study, we investigated the mechanism by which human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) inhibit inflammation in IBD mouse and macrophage inflammation models. Methods […]
Stem cell therapy found to boost fertility in women with ovarian failure
Author(s)Celeste Krewson, Assistant Editor Fact checked by: Morgan Ebert, Managing Editor A new study reveals that stem cell treatment activates oocytes in 70% of women with ovarian failure. Stem cell therapy found to boost fertility in women with ovarian failure | Image Credit: © Anusorn – © Anusorn – stock.adobe.com. Stem cell therapy found to […]
Paralysed man stands again after receiving ‘reprogrammed’ stem cells
Another man also regained some movement, but two others experienced minimal improvement. By Smriti Mallapaty Twitter Facebook Email A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal-cord injury. The Japanese man was one of four individuals in a first-of-its-kind trial that used reprogrammed stem […]
Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway
Abstract Background Exosomes isolated from human umbilical cord mesenchymal stem cells (hUCMSCs) have demonstrated the capacity to alleviate dihydrotestosterone (DHT)-induced disruptions in the hair follicle growth cycle. However, the precise role and underlying mechanisms by which hUCMSC-derived exosomes influence hair shaft regeneration in androgenetic alopecia (AGA) remains unclear. Methods hUCMSCs were isolated using fluorescence-activated cell […]
Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes
Desheng Chen, Zeping Chen, Jiabin Yuan, Guanzi Chen, Yutao Chen, Kaiming He, Yongwei Hu, Linsen Ye & Yang Yang Stem Cell Research & Therapy volume 16, Article number: 259 (2025) Cite this article 2250 Accesses 1 Citations Metricsdetails Abstract Background Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) have gained significant attention for their potential […]
FDA Approves First-Ever Cell Therapy Treatment for Rare Progressive Eye Disease
The FDA has approved the first – and only – treatment, a cell therapy, for macular telangiectasia type 2 (MacTel), a rare neurodegenerative disease that causes irreversible vision loss. The treatment, Encelto (revakinagene taroretcel-lwey), is an encapsulated cell therapy, developed by Neurotech Pharmaceuticals, that continually delivers therapeutic doses of ciliary neurotrophic factor to the retina, […]