Source: Stem cell therapy found to boost fertility in women with ovarian failure, Contemporary OB/GYN, Jul 2025. Summary written by Future Health GCC.

What happened

A study published in the journal Aging in 2025 looked at a fertility treatment called the Stem Cell Regenera protocol in 145 women, with an average age of 39, who had diminished ovarian reserve, a poor response to IVF, or premature ovarian insufficiency.

What the treatment involves

Over four days, women took a medicine called G-CSF, which moves stem cells from the bone marrow into the bloodstream. These were then used alongside an injection into the ovaries of platelet-rich plasma enriched with stem cell factor. The aim was to stimulate the ovaries to start producing eggs again.

What they found

Egg activation, measured as an increase of at least three follicles on ultrasound, was seen in 68% of the women. About 7% became pregnant naturally and 14% became pregnant through IVF. No pregnancies occurred in women whose ovaries did not respond. Women under 38 were more likely to respond.

Just over half of the women reported no side effects, 33% had mild side effects and 14% had moderate to severe ones.

How far along it is

This was a retrospective study of patients treated in routine practice, with no comparison group of women who did not have the treatment. That means it cannot show how many of these pregnancies were caused by the treatment. The researchers say further research is needed to confirm the results.

What it means for families

It adds to growing interest in stem cell-based approaches to fertility. It is not an established treatment, and anyone affected should discuss options with a fertility specialist.

Read the original article on Contemporary OB/GYN →

This is a summary of published research, written by Future Health GCC. It is not medical advice. Speak to your doctor about any treatment.

Photo: Unknown photographer, via Wikimedia Commons (public domain).