FDA Approves First Mesenchymal Stromal Cell Therapy to Treat Steroid-refractory Acute Graft-versus-host Disease
For Immediate Release: December 18, 2024 Today, the U.S. Food and Drug Administration approved Ryoncil (remestemcel-L-rknd), an allogeneic (donor) bone marrow-derived mesenchymal stromal cell (MSC) therapy indicated for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD) in pediatric patients 2 months of age and older. Ryoncil is the first FDA-approved MSC therapy. It contains MSCs, […]
Exosomal miR-133b-3p modulates TGF-β1/Treg immunomodulation to ameliorate osteoporosis
Abstract Purpose Osteoporosis (OP) is influenced by dysregulated miRNAs, particularly during osteoblast differentiation. The precise mechanisms are still under debate. This study aimed to explore the impact of bone marrow mesenchymal stem cells (BMSCs)-derived exosomal miR-133b-3p on the TGF-β1/Treg-mediated immune pathway, offering insights into OP’s pathogenesis and potential therapeutic targets. Materials and methods Bioinformatics analysis […]
Stem cell therapy found to boost fertility in women with ovarian failure
Author(s)Celeste Krewson, Assistant Editor Fact checked by: Morgan Ebert, Managing Editor A new study reveals that stem cell treatment activates oocytes in 70% of women with ovarian failure. Stem cell therapy found to boost fertility in women with ovarian failure | Image Credit: © Anusorn – © Anusorn – stock.adobe.com. Stem cell therapy found to […]
Paralysed man stands again after receiving ‘reprogrammed’ stem cells
Another man also regained some movement, but two others experienced minimal improvement. By Smriti Mallapaty Twitter Facebook Email A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal-cord injury. The Japanese man was one of four individuals in a first-of-its-kind trial that used reprogrammed stem […]
FDA Approves First-Ever Cell Therapy Treatment for Rare Progressive Eye Disease
The FDA has approved the first – and only – treatment, a cell therapy, for macular telangiectasia type 2 (MacTel), a rare neurodegenerative disease that causes irreversible vision loss. The treatment, Encelto (revakinagene taroretcel-lwey), is an encapsulated cell therapy, developed by Neurotech Pharmaceuticals, that continually delivers therapeutic doses of ciliary neurotrophic factor to the retina, […]
Application of Mesenchymal Stem Cells in Female Infertility Treatment: Protocols and Preliminary Results
Application of Mesenchymal Stem Cells in Female Infertility Treatment: Protocols and Preliminary Results Abstract Infertility is a global phenomenon that impacts people of both the male and the female sex; it is related to multiple factors affecting an individual’s overall systemic health. Recently, investigators have been using mesenchymal stem cell (MSC) therapy for female-fertility-related disorders […]
Exploring the therapeutic potential of different sources of mesenchymal stem cells: a novel approach to combat burn wound infections
Exploring the therapeutic potential of different sources of mesenchymal stem cells: a novel approach to combat burn wound infections Abstract The most prevalent and harmful injuries are burns, which are still a major global health problem. Burn injuries can cause issues because they boost the inflammatory and metabolic response, which can cause organ malfunction and […]
Pain Relief with Stem Cell IV Therapy
Pain Relief with Stem Cell IV Therapy Clinical research on the benefits of stem cell therapy has risen significantly in recent decades. The most promising aspect of stem cell IV therapy is that it offers relief to patients with chronic pain and hard-to-heal injuries, all without drugs or complex reconstructive surgeries. Researchers are also unearthing […]
Efficacy and safety of mesenchymal stem cells in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials
Efficacy and safety of mesenchymal stem cells in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials Abstract Background The aim of this meta-analysis was to investigate the efficacy and safety of intra-articular injection of mesenchymal stem cells (MSCs) alone for the treatment of unoperated knee osteoarthritis (OA). Methods Four databases were systematically […]
Stem Cells: Anti-Aging Treatment Breakthrough in 2025?
Stem Cells: Anti-Aging Treatment Breakthrough in 2025? Regenerative stem cell therapy rejuvenates existing cell types Introducing “youthful” human stem cells into the body can rejuvenate existing cells and allow the body to age more gracefully & even reverse some effects of the aging process. As we age, our cells get sick and die. When a cell dies, […]