Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging
Highlights • The hallmarks of aging are diverse and the features interact with each other rather than being independent of each other. This article wants to use hallmarks of aging as an entry point to explore whether improving the relevant indicators can delay aging. • Mesenchymal stem cells have strong tissue regeneration and repair ability, […]
Clinical applications of stem cell-derived exosomes
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared to stem cells, stem cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic potential and ethical […]
Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis
Ferroptosis, a regulated type of cell death directed by iron-dependent lipid peroxidation, is associated with a variety of pathological diseases. Recent findings have highlighted the therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in modulating ferroptosis. These nano-sized extracellular vesicles carry bioactive substances, including proteins, lipids, and microRNAs, which regulate vital pathways related to ferroptosis, […]
Injection of human umbilical cord mesenchymal stem cells exosomes for the treatment of knee osteoarthritis: from preclinical to clinical research
Abstract Background Background: Exosomes (Exos) derived from mesenchymal stem cells (MSCs) share similar biological functions with MSCs but are more stable under various pathophysiological conditions, with a lower risk of immune rejection. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are a promising source of MSC-derived exosomes (MSC-Exos), particularly for the treatment of osteoarthritis (OA), a […]
Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair
Abstract Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond. Exosomes, small extracellular vesicles secreted by various stem cells, have emerged as potent mediators of […]
Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration
Abstract Despite significant strides in medical treatments and surgical procedures for cardiovascular diseases, these conditions continue to be a major global health concern. The persistent need for innovative therapeutic approaches to mend damaged heart tissue highlights the complexity and urgency of this medical challenge. In recent years, stem cells have emerged as a promising tool […]
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages
Abstract Background Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study, we investigated the mechanism by which human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) inhibit inflammation in IBD mouse and macrophage inflammation models. Methods […]
Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway
Abstract Background Exosomes isolated from human umbilical cord mesenchymal stem cells (hUCMSCs) have demonstrated the capacity to alleviate dihydrotestosterone (DHT)-induced disruptions in the hair follicle growth cycle. However, the precise role and underlying mechanisms by which hUCMSC-derived exosomes influence hair shaft regeneration in androgenetic alopecia (AGA) remains unclear. Methods hUCMSCs were isolated using fluorescence-activated cell […]
Research landscape and trends of human umbilical cord mesenchymal stem cell-derived exosomes
Desheng Chen, Zeping Chen, Jiabin Yuan, Guanzi Chen, Yutao Chen, Kaiming He, Yongwei Hu, Linsen Ye & Yang Yang Stem Cell Research & Therapy volume 16, Article number: 259 (2025) Cite this article 2250 Accesses 1 Citations Metricsdetails Abstract Background Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) have gained significant attention for their potential […]
Exosome Iv Infusion: A Promising Approach to Wellness and Recovery
Exosome Iv Infusion: A Promising Approach to Wellness and Recovery Exosome therapy is a burgeoning field of regenerative medicine that utilizes the potential of exosomes, tiny extracellular vesicles, to facilitate healing and improve cellular function. Intravenous (IV) infusion of exosomes has emerged as a novel treatment, demonstrating promising results in clinical trials, such as reduced […]