Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway
Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway Abstract Traumatic brain injury (TBI) is a predominant cause of death and permanent disability globally. In recent years, much emphasis has been laid on treatments for TBI. Increasing evidence suggests […]
Mesenchymal stem cells and mesenchymal stem cell-derived exosomes: a promising strategy for treating retinal degenerative diseases
Mesenchymal stem cells and mesenchymal stem cell-derived exosomes: a promising strategy for treating retinal degenerative diseases Abstract Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic strategy in regenerative medicine, demonstrating significant potential for clinical applications. Evidence suggests that MSCs not only exhibit multipotent differentiation potential but also exert critical therapeutic effects in retinal […]
Therapeutic effect of mesenchymal stem cells and their derived exosomes in diseases
Abstract Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by their robust proliferative capacity, homing ability, differentiation potential, and low immunogenicity in vitro. MSCs can be isolated from a variety of tissues, primarily including but not limited to bone marrow, adipose tissue, umbilical cord, placenta, and dental pulp. Although there have been a large […]
Progress of mesenchymal stem cells (MSCs) & MSC-Exosomes combined with drugs intervention in liver fibrosis
Progress of mesenchymal stem cells (MSCs) & MSC-Exosomes combined with drugs intervention in liver fibrosis Highlights Drugs promote homing and differentiation of MSCs into hepatoid cells. MSC-Exos can act as a drug delivery vehicle; drugs enhance MSC-Exos targeting. MSCs & MSC-Exos combined with drugs modulate microenvironment and signaling pathways. Combination strategy more effective than single […]
Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseases
Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseases Abstract Mesenchymal stem/stromal cells (MSCs) and their exosomes (MSC-Exos) have great potential for tissue repair and regenerative medicine, which can improve the symptoms and prognosis of aging-related diseases and potentially slow the aging process through multiple pathways. This comprehensive review summarizes the […]
Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth
Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth The skin covers the surface of the body and acts as the first defense barrier against environmental damage. Exposure of the skin to environmental physical and chemical factors such as mechanical injuries, UV rays, air pollution, chemicals, etc. Leads to […]
Stem cell exosomes may be hypoxic pulmonary hypertension therapy
Stem cell exosomes may be hypoxic pulmonary hypertension therapy Exosomes — very small, sac-like structures — derived from stem cells may offer a potential treatment for hypoxic pulmonary hypertension (HPH) by preventing the abnormal growth and movement of muscle cells lining blood vessels. That’s according to data from a new study, conducted by researchers in China using […]
Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging
Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging Highlights • The hallmarks of aging are diverse and the features interact with each other rather than being independent of each other. This article wants to use hallmarks of aging as an entry point to explore whether improving the relevant indicators can delay aging. […]
Clinical applications of stem cell-derived exosomes
Clinical applications of stem cell-derived exosomes Abstract Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared to stem cells, stem cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, […]
Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis
Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis Abstract Ferroptosis, a regulated type of cell death directed by iron-dependent lipid peroxidation, is associated with a variety of pathological diseases. Recent findings have highlighted the therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in modulating ferroptosis. These nano-sized extracellular vesicles carry bioactive substances, […]